The Science Behind PRP and Polynucleotides in Modern Facial Rejuvenation

Estimated read time 2 min read

What if aging could be reversed not by adding foreign substances into the face, but by activating the body’s own regenerative processes? That’s the promise behind Dr. Hanna Shabanova’s BioLifting Structure™ method, which harnesses the combined power of PRP and polynucleotides.

Understanding the Biological Tools

PRP (Platelet-Rich Plasma) is derived from a patient’s own blood. After centrifugation, it yields a concentration of platelets rich in growth factors that stimulate tissue repair, collagen production, and angiogenesis. PRP has been used in wound healing, orthopedics, and now — aesthetic medicine.

Polynucleotides (PDRN), on the other hand, are DNA fragments derived from salmon sperm, known for their biocompatibility and regenerative power. They work by activating cellular repair mechanisms, stimulating fibroblasts, and improving dermal thickness.

Why Use Both?

Dr. Hanna Shabanova explains: “PRP is like the ignition. It sparks the repair response. Polynucleotides are the fuel — they sustain that process and rebuild the skin’s matrix.”

Dr. Hanna Shabanova

Her technique layers both substances at different depths:

  • PRP in superficial layers to boost glow and microcirculation
  • PN in mid to deep dermis to restore structure and resilience
  • Combined injections under retaining ligaments to stabilize facial contours

Evidence-Based Medicine

Dr. Shabanova’s work is supported by clinical research. Studies from Mendelson, Galeano, and Gentile confirm the biological benefits of PDRN in tissue healing and PRP’s effects on neocollagenesis. Her method translates theory into practice, showing measurable improvements in dermal density, elasticity, and structural integrity.

Her clinical notes are documented in over 100 anonymized cases, which she uses in lectures for continuing medical education (CME) events. She is also preparing to publish her comparative data in an international peer-reviewed journal.

Clinical Impact

In over 200 patients treated with her protocol, Dr. Shabanova documented:

  • 28% increase in dermal firmness after 2 sessions
  • Visible lifting of midface and jawline
  • Long-term improvement in skin hydration and texture
  • 91% patient satisfaction at 6-month follow-up

In addition to visual results, patients reported a reduction in skin sensitivity, acne reoccurrence, and post-inflammatory pigmentation — benefits rarely associated with filler-based techniques.

BioLifting Structure™ bridges the gap between beauty and biology. By using tools already present in the body, Dr. Shabanova has redefined what it means to rejuvenate — not by masking time, but by rewriting its effects.

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